Prognostic analysis of preoperative CONUT score combined with serum CEA in patients undergoing thoracoscopic radical resection of non-small cell lung cancer
Objective To analyze the Controlling Nutritional Status Score(CONUT)controlling nutritional status score(CONUT)combined with serum Carcinoembryonic Antigen,Prognostic value of CEA in patients undergoing thoracoscopic radical resection of non-small cell lung cancer.Methods The clinical data of 148 patients with Non-Small Cell Lung Cancer(NSCLC)in the 970th Hospital of the Chinese People's Liberation Army Joint Logistics Support Force from January 2022 to December 2023 were retrospectively analyzed.All patients underwent thoracoscopic radical resection of NSCLC.According to the prognosis,patients were divided into poor prognosis group(n=42)and good prognosis group(n=106).General data,preoperative CONUT score and serum CEA level of the two groups were compared,and the risk factors affecting prognosis were analyzed by Logistic regression.Receiver operationcurve(ROC)curve was used to evaluate the prognostic value of preoperative CONUT score and serum CEA in patients undergoing thoracoscopic radical resection of non-small cell lung cancer.Results Comparison of clinical staging,depth of invasion,tumor diameter,treatment modality,CONUT score,and serum CEA between the two groups showed statistically significant differences(P＜0.05).Multivariate logistic regression analysis indicated that clinical staging,treatment modality,CONUT score,and serum CEA are risk factors affecting the prognosis of patients undergoing thoracoscopic radical surgery for non-small cell lung cancer(NSCLC)(P＜0.05).ROC curve analysis demonstrated that the combined prediction of CONUT score and serum CEA for the prognosis of patients undergoing thoracoscopic radical surgery for NSCLC had an AUC of 0.982(95%CI:0.964-0.999),with a sensitivity of 91.6%and specificity of 94.3%,which was superior to the individual predictions of CONUT score and serum CEA.Conclusion Clinical staging,treatment modality,CONUT score,and serum CEA are risk factors affecting the prognosis of patients undergoing thoracoscopic radical surgery for non-small cell lung cancer(NSCLC).Combined assessment of CONUT score and serum CEA can provide more accurate prognostic information and has a higher predictive value.
CONUT scoreSerum CEAThoracoscopeNon-small cell lung cancerRadical resection of lung cancer
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