Analgesic effect of midazolam combined with fentanyl in mechanically ventilated children with severe pneumonia
Objective To explore the analgesic effect of midazolam combined with fentanyl in mechanically ventilated children with severe pneumonia.Methods Eighty children with mechanically ventilated severe pneumonia were studied,all of whom were admitted to hospital between January 2023 and June 2024.Group A(n=40)was given single-drug sedation and analgesia with midazolam,group B(n=40)was given fentanyl on the basis of group A.Blood pressure,heart rate,sedation and analgesia effect,mechanical ventilation time and hospital stay were compared.Results HR,SBP and DBP in different time periods were compared,and there were no differences between the two groups before medication(P＞0.05),while the HR,SBP and DBP in group B were lower than those in group A at 6h and 24h after medication(P＜0.05).Before medication,Ramsay and FLACC scores of the two groups were compared(P＞0.05).After 6h and 24h,Ramsay score in group B was higher than that in group A,FLACC score was lower than that in group A,and there were differences between the two groups(P＜0.05).The hospitalization time and mechanical ventilation time in group B were shorter than those in group A(P<0.05).Conclusion Midazolam combined with fentanyl can stabilize the hemodynamics of mechanically ventilated children with severe pneumonia,and has good sedative and analgesic effect,which is worthy of reference and application.
Mechanical ventilationSevere pneumoniaChildren with childrenMidazolamfentanyl
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