硫代硫酸钠联合骨化三醇治疗维持性血液透析患者血管钙化的效果观察
Observation of the effect of sodium thiosulfate combined with calcitriol in the treatment of vascular calcification in maintenance hemodialysis patients
黄玲1
作者信息
- 1. 江西省吉安市中心人民医院,江西 吉安 343000
- 折叠
摘要
目的 探讨硫代硫酸钠(STS)联合骨化三醇治疗维持性血液透析(MHD)患者血管钙化的效果观察.方法 按照随机数表法将2023年5月-2024年5月我院收治的68例MHD患者分为两组,每组各34例,对照组给予骨化三醇治疗,联合组给予STS联合骨化三醇治疗.对比两组血管钙化程度[冠状动脉钙化评分(CASs)]、生化指标[血磷、血钙、甲状旁腺激素(iPTH)]、炎症因子[白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)]、不良反应.结果 两组治疗前CASs评分比较,无明显差异(P＞0.05),治疗后联合组CASs评分低于对照组(P＜0.05).两组治疗前生化指标比较,无明显差异(P＞0.05),治疗后联合组生化指标均低于对照组(P＜0.05).两组治疗前炎症因子水平比较,无明显差异(P＞0.05),治疗后联合组炎症因子水平均低于对照组(P＜0.05).两组不良反应比较,无明显差异(P＞0.05).结论 MHD患者血管钙化使用STS联合骨化三醇治疗可有效预防血管钙化,调节血钙和血磷平衡,降低iPTH水平,减少炎症反应,且不会增加不良反应,治疗安全可靠.
Abstract
Objective To investigate the effect of sodium thiosulfate(STS)combined with calcitriol in the treatment of vascular calcification in maintenance hemodialysis(MHD)patients.Methods Sixty eight patients with MHD admitted to our hospital from May 2023 to May 2024 were randomly divided into two groups,with 34 patients in each group.The control group received calcitriol treatment,while the combination group received STS combined with calcitriol treatment.Compare two groups of vascular calcification[coronary artery calcification score(CASs)],biochemical indicators[blood phosphorus,blood calcium,parathyroid hormone(iPTH)],inflammatory factors[interleukin-6(IL-6),high-sensitivity C-reactive protein(hs-CRP)],and adverse reactions.Results There was no significant difference in the CASs scores between the two groups before treatment(P＞0.05),and the CASs scores in the combination group were lower than those in the control group after treatment(P＜0.05).There was no significant difference in biochemical indicators between the two groups before treatment(P＞0.05),and after treatment,the biochemical indicators in the combination group were lower than those in the control group(P＜0.05).There was no significant difference in inflammatory factors between the two groups before treatment(P＞0.05),and after treatment,the inflammatory factors in the combination group were lower than those in the control group(P＜0.05).There was no significant difference in adverse reactions between the two groups(P＞0.05).Conclusion The use of STS combined with calcitriol in the treatment of vascular calcification in MHD patients can effectively prevent vascular calcification,regulate blood calcium and phosphorus balance,reduce iPTH levels,decrease inflammatory reactions,and do not increase adverse reactions.The treatment is safe and reliable.
关键词
维持性血液透析/血管钙化/硫代硫酸钠/骨化三醇/甲状旁腺激素/炎症反应Key words
Maintenance hemodialysis/Vascular calcification/Sodium thiosulfate/Calcitriol/Parathyroid hormone/inflammatory reaction引用本文复制引用
出版年
2025
NETL
NSTL
万方数据