目的 探讨铝碳酸镁混悬液联合云南白药对非静脉曲张性急性上消化道出血(Non variceal acute upper gastrointestinal bleeding，ANVUGIB)的应用效果及对红细胞分布宽度(Red blood cell distribution width，RDW)、血小板分布宽度(Platelet distribution width，PDW)水平影响。方法 前瞻性选取我院2021年8月-2024年6月收治的120例ANVUGIB患者展开研究，按抽签法分为铝碳酸镁组与联合组，每组各60例。铝碳酸镁组采用铝碳酸镁混悬液治疗，联合组采用铝碳酸镁混悬液联合云南白药治疗。对比两组临床疗效、完全止血时间、血压稳定时间、住院时间、再出血发生率及输血率，治疗前后RDW、PDW水平，最后对比其内镜评分变化。结果 联合组总有效率93。33%高于铝碳酸镁组的78。33%(P＜0。05);联合组完全止血时间、血压稳定时间、住院时间短于铝碳酸镁组，联合组再出血发生率5。00%、输血率20。00%低于铝碳酸镁组的16。67%，38。33%(P＜0。05);治疗后联合组RDW、PDW水平均低于铝碳酸镁组(P＜0。05);联合组治疗后1d、治疗后2d、治疗后3d内镜评分低于铝碳酸镁组(P＜0。05)。结论 针对ANVUGIB患者采取铝碳酸镁混悬液联合云南白药治疗疗效更优，可缩短止血时间、血压异常时间及住院时间，降低再出血率及输血率，改善治疗后RDW、PDW水平，减轻内镜下症状。
The application effect of aluminum magnesium carbonate suspension combined with Yunnan Baiyao on non variceal acute upper gastrointestinal bleeding and its impact on RDW and PDW levels
Objective To investigate the application effect of aluminum magnesium carbonate suspension combined with Yunnan Baiyao on non variceal acute upper gastrointestinal bleeding(ANVUGIB)and its impact on the levels of red blood cell distribution width(RDW)and platelet distribution width(PDW).Methods A prospective study was conducted on 120 ANVUGIB patients admitted to our hospital from August 2021 to June 2024.They were randomly divided into a aluminum magnesium carbonate group and a combination group,with 60 patients in each group.The aluminum magnesium carbonate group was treated with aluminum magnesium carbonate suspension,while the combination group was treated with aluminum magnesium carbonate suspension combined with Yunnan Baiyao.Compare the clinical efficacy of two groups,including complete hemostasis time,blood pressure stabilization time,hospitalization time,incidence of rebleeding and transfusion rate,RDW and PDW levels before and after treatment,and finally compare the changes in endoscopic scores.Results The total effective rate of the combined group was 93.33%higher than that of the aluminum magnesium carbonate group(78.33%)(P＜0.05);the complete hemostasis time hours,blood pressure stabilization time hours,and hospitalization time days in the combination group were shorter than those in the aluminum magnesium carbonate group.The incidence of rebleeding and transfusion rate in the combination group were 5.00%and 20.00%,respectively,lower than those in the aluminum magnesium carbonate group(16.67%,38.33%)(P＜0.05);after treatment,the RDW of the combination group was lower than that of the aluminum magnesium carbonate group,and the PDW was lower than that of the aluminum magnesium carbonate group(P＜0.05);the endoscopic scores of the combination group were lower than those of the aluminum magnesium carbonate group on 1d,2d and 3d after treatment(P＜0.05).Conclusions The combination of aluminum carbonate magnesium suspension and Yunnan Baiyao has a better therapeutic effect on ANVUGIB patients,which can shorten hemostasis time,abnormal blood pressure,hospitalization time,reduce rebleeding rate and bleeding rate,improve RDW and PDW levels after treatment,and alleviate endoscopic symptoms.
Magnesium aluminum carbonate suspensionYunnan BaiyaoNon variceal acute upper gastrointestinal bleedingPlatelet distribution widthRed blood cell distribution width
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