Effect of combined detection of β2-microglobulin,urea nitrogen,creatinine,cystatin C and glycated hemoglobin on diagnostic accuracy of renal function in patients with type 2 diabetes
Objective To analyze the effect of combined detection of β2-microglobulin,urea nitrogen,creatinine,cystatin C and glycated hemoglobin in renal function in patients with type 2 diabetes.Methods From January 2022 to February 2024,80 patients were selected in our hospital,30 healthy subjects were selected as control group,25 patients with type 2 diabetes kidney injury were selected as observation group A,and 25 patients with simple type 2 diabetes were selected as observation group B.The renal function indexes and HBA1c values of the three groups were analyzed.Results Compared with the control group,the levels of β2-microglobulin,urea nitrogen,serum creatinine and cystatin C in observation groups A and B were higher,and the levels of β2-microglobulin,urea nitrogen,serum creatinine and cystatin C in observation group A were significantly higher than those in observation group B,with statistical significance(P＜0.05);the levels of glycosylated hemoglobin in observation groups A and B were higher than those in control group,the comparison was statistically significant(P＜0.05).In ROC curve analysis of diabetes-related test indicators,SE was 0.04,AUC(area under the curve)was 0.807,and 95%CI were 0.738-0.864(P＜0.05).Conclusion The combination test of β2-microglobulin,urea nitrogen,serum creatinine,cystatin C and glycated hemoglobin is beneficial for physicians to observe the development of type 2 diabetes patients,and provides a reliable basis for targeted treatment and judgment of prognosis and recovery effect.It is highly sensitive and worthy of clinical recommendation.
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