Clinical observation and safety analysis of belizumab combined with prednisone acetate and tacrolimus in the treatment of lupus nephritis
Objective To observe the clinical effect of belizumab combined with prednisone acetate and tacrolimus in the treatment of lupus nephritis(LN)and analyze its safety.Methods 74 patients with LN were randomly divided into two groups according to the numerical table method,with 37 cases in each group.The control group was treated with prednisone acetate combined with tacrolimus,and the observation group was treated with intravenous drip of belizumab on the basis of the control group.The curative effects of the two groups were compared.The renal function indexes of BUN,Scr,Cys C and the immunological indexes of complement C3,complement C4,IgG and IgM of the two groups before and after treatment were detected.Meanwhile,the occurrence of various adverse reactions in the two groups was observed.Results The total effective rate in the observation group(91.89%)was significantly higher than that in the control group(72.97%)(P＜0.05).There was no significant difference in renal function and immunological indexes between the two groups before treatment(P＞0.05).After treatment,the complement C3 and C4 in the two groups increased significantly(P＜0.05),while the renal function indexes of BUN,Scr,Cys C and IgG,IgM decreased significantly(P＜0.05),and the increase and decrease in the observation group were more obvious than those in the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups during treatment(P＞0.05).Conclusion The treatment of berizumab combined with prednisone acetate and tacrolimus for the LN patients has a marked curative effect,it can effectively improve the patient's renal function and regulate the immune state,and will not increase adverse reactions.
NETL
NSTL
万方数据
