首页|硫辛酸注射液联合依帕司他治疗2型糖尿病周围神经病变临床疗效及对神经传导速度的影响

硫辛酸注射液联合依帕司他治疗2型糖尿病周围神经病变临床疗效及对神经传导速度的影响

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目的 探讨2型糖尿病周围神经病变患者应用硫辛酸注射液联合依帕司他治疗的效果及对其神经传导速度、炎症反应的影响.方法 本研究为前瞻性研究,研究对象:2型糖尿病周围神经病变患者,选取总样本量:97例,选例时间:2020年7月-2022年12月,将其分为两组:对照组、试验组(随机数表法),前者纳入48例研究对象并采用硫辛酸注射液治疗;后者纳入49例研究对象并在前者基础上采用依帕司他治疗.治疗时间:均持续2个月.比较两组各项指标.结果 治疗后,两组(试验组、对照组)临床总有效率相比(93.88%vs 79.17%),前者更高,差异显著(P<0.05).两组(对照组、试验组)治疗后正中神经、腓总神经SNCV、MNCV均较治疗前升高,且试验组治疗后水平更高(P<0.05).两组(对照组、试验组)治疗后血清IL-8、IL-17、TNF-α水平均较治疗前降低,且试验组治疗后水平更低(P<0.05).两组(对照组、试验组)不良反应总发生率相比(12.50%vs 14.29%),差异无统计学意义(治疗期间)(P>0.05).结论 2型糖尿病周围神经病变患者应用硫辛酸注射液联合依帕司他治疗效果显著,有助于减轻患者炎症反应,改善神经传导速度,且安全性好.
Clinical efficacy of lipoic acid injection combined with epalrestat in the treatment of type 2 diabetic peripheral neuropathy and its influence on nerve conduction velocity
Objective To investigate the effect of lipoic acid injection combined with epalrestat on patients with type 2 diabetic peripheral neuropathy and its influence on nerve conduction velocity and inflammatory response.Methods This study was a prospective study,the research objects:patients with type 2 diabetic peripheral neuropathy,the total sample size:97 cases,selection time:July 2020 to December 2022,they were divided into two groups:control group,experimental group(random number table method),the former included 48 cases and treated with lipoic acid injection;49 patients in the latter group were treated with epalrestat on the basis of the former group.The duration of treatment was 2 months.The indexes of the two groups were compared.Results After treatment,the total effective rate of the two groups(experimental group,control group)was 93.88%,compared with 79.17%,the former was higher,the difference was statistically significant(P<0.05).The SNCV and MNCV of median nerve and common peroneal nerve in the two groups(control group,experimental group)were increased(after treatment compared with before treatment,within the group),and the latter was higher(after treatment,between the groups)(P<0.05).The serum levels of IL-8,IL-17 and TNF-α in the two groups(control group,experimental group)were decreased(after treatment compared with before treatment,within the group),and the latter was lower(after treatment,between the groups)(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(control group,experimental group)(12.50%vs 14.29%)(P>0.05).Conclusions Lipoic acid injection combined with epalrestat is effective in the treatment of type 2 diabetic peripheral neuropathy,which can reduce the inflammatory response and improve nerve conduction velocity,and has good safety.

Diabetic peripheral neuropathyEpalrestatα-lipoic acidNerve conduction velocityInflammatory response

刘冬、霍福贵

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通用医疗哈尔滨二四二医院,黑龙江 哈尔滨 150066

糖尿病周围神经病变 依帕司他 α-硫辛酸 神经传导速度 炎症反应

2025

首都食品与医药
《首都医药》杂志社

首都食品与医药

影响因子:0.389
ISSN:1005-8257
年,卷(期):2025.32(2)