Analysis of dynamic contrast-enhanced magnetic resonance imaging features in patients with recurrent and pseudoprogression of brain glioma after surgery
Objective To investigate the characteristics of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)in patients with postoperative recurrence and false progression of glioma.Methods A total of 80 patients with cerebral glioma treated in our hospital from March 2023 to August 2024 after concurrent radiotherapy and chemotherapy were selected.All patients received DCE-MRI examination 3 months after radiotherapy and chemotherapy.According to the pathological examination of the second operation or follow-up results,the patients were divided into recurrence group(47 cases)and false progression group(33 cases).The clinical characteristics,DCE-MRI parameters of the two groups were compared,multivariate analysis and ROC curve were used to analyze the influencing factors and diagnostic value of postoperative recurrence and false progression of glioma.Results There have differences in SVZ invasion,IDH genotype and MGMT promoter methylation between the two groups before surgery(P＜0.05).The volume transport constant,Ve and iAUC in the lesion parenchyma in the recurrence group were significantly higher than those in the false progression group(P＜0.05).Binary Logistic analysis showed that preoperative invasion of SVZ region,IDH gene wild type,MGMT promoter unmethylation,volume transport constant of lesion parenchyma,Ve and iAUC were risk factors for postoperative recurrence of glioma(P＜0.05).The ROC results were as follows:AUC of volume transport constant was 0.787,AUC of Ve was 0.901,AUC of iAUC was 0.647,and AUC of combined detection was 0.932(P＜0.05).Conclusion DCE-MRI detection of the transport constant,Ve and iAUC in the lesion parenchyma can be used for the diagnosis of postoperative recurrence and false progression of glioma,and the combined application of 3 cases has the highest diagnostic value.
Brain gliomaPostoperative recurrencePseudoprogressionDynamic comparisonEnhanced magnetic resonance imaging
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