药学研究2024,Vol.43Issue(1) :74-82.DOI:10.13506/j.cnki.jpr.2024.01.014

忍冬属植物中咖啡酰奎宁酸类成分及其吸收与代谢研究进展

Research progress on caffeoylquinic acids in Lonicera L.and their absorption and metabolism

田海涛 张喆 赵盼 李静 张四喜 邓志鹏
药学研究2024,Vol.43Issue(1) :74-82.DOI:10.13506/j.cnki.jpr.2024.01.014

忍冬属植物中咖啡酰奎宁酸类成分及其吸收与代谢研究进展

Research progress on caffeoylquinic acids in Lonicera L.and their absorption and metabolism

田海涛 1张喆 1赵盼 1李静 1张四喜 2邓志鹏1
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作者信息

  • 1. 山东中医药大学,山东济南 250355
  • 2. 吉林大学第一医院药学部,吉林长春 130021
  • 折叠

摘要

迄今为止从忍冬属植物中分离出24种咖啡酰奎宁酸类化合物,此类化合物显示有多种药理活性,具备广阔的应用前景,吸收与代谢研究发现其主要吸收部位为小肠,以被动扩散为主,代谢部位主要在大肠,代谢途径有甲基化、葡萄糖醛酸结合、水解、异构化和还原反应等.本文对忍冬属植物中咖啡酰奎宁酸类成分及其吸收与代谢研究进行总结,以期为咖啡酰基奎宁酸类药物研究开发提供参考.

Abstract

Caffeoylquinic acids are very important natural products with a variety of pharmacological activities and broad research prospects.By retrieving related literature,it was reported that 24 caffeoylquinic acids have been isolated from Lonicera L.so far.Absorption and metabolism research found that the main absorption site of caffeoylquinic acids is the small intestine,with passive diffusion as the main site,and the metabolic site is mainly in the large intestine.The metabolic path-ways include methylation,glucuronidation,hydrolysis,isomerization and reduction reactions.This paper summarizes the chemical structures of caffeoylquinic acids in Lonicera L.and their absorption and metabolism,in order to provide reference for the research and development of caffeoylquinic acids.

关键词

忍冬属/咖啡酰奎宁酸/吸收与代谢/研究进展

Key words

Lonicera L./Caffeoylquinic acids/Absorption and metabolism/Research progress

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基金项目

山东省自然科学基金-面上项目(ZR2019MH051)

山东省中医药科技项目(M-2023191)

山东省医药卫生科技发展计划项目(202213030509)

出版年

2024
药学研究
山东省药品检验所 山东省药学会

药学研究

CSTPCD
影响因子:0.653
ISSN:2095-5375
参考文献量68
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