Research and development progress of anti-tumor drug targeting transcription factors
Transcription factor(TF)control many normal cellular processes such as cell growth and proliferation,me-tabolism,apoptosis,immune response and differentiation by binding to DNA-regulatory sequences.TFs are often dysregulated in cancer and associate with initiation and progression of cancer.Therefore targeting TFs provides new ideas for the development of anticancer drugs.However,drug design targeting TFs faces challenges because of structural disorder and lack of binding pockets.This review was focused on the advances and successes in the development of small molecules targe-ting TFs and demonstrates feasibility of drug discovery targeting TFs and provides paradigms for the development of drugs targeting TFs.
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