Influenza is a respiratory infectious disease caused by influenza virus,which is more harmful to human health.At present,the main problems faced by anti influenza drugs are virus resistance and low potency for highly pathogenic influenza virus.Due to the shortcomings of influenza drugs such as M2 ion channel inhibitor and neuraminidase inhibitor,such as low efficacy,narrow time window and drug resistance,recent anti influenza drug development focuses on viral RNA polymerase.Influenza virus RNA polymerase is a key enzyme for virus replication and transcription in host cells.The PA sub-unit provides primers for the transcription process of influenza virus through endonuclease activity and becomes a potential anti influenza drug target.Therefore,this article summarized the research progress of anti influenza drugs targeting the activity of PA subunit endonuclease,aiming to provide a reference for the development of new safe and effective antiviral RNA polymerase inhibitors.
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