Mechanism of hawthorn in treating hyperlipidemia based on network pharmacology and molecular docking
Objective To explore the mechanism of hawthorn in treating hyperlipidemia by network pharmacology and molecular docking technology.Methods The effective components of hawthorn and their corresponding targets were obtained by HERB,ETCM,SymMap,BATMAN-TCM,PubChem,SwissTargetPretiction,UniProt database and literature sup-plement.The related targets of hyperlipidemia were collected by GeneCards,OMIM and DAVID databases,and GO and KEGG enrichment analysis were performed on the intersection targets.The main components and targets were molecularly docked using Open Babel GUI and AutoDockTools-1.5.7 software.Finally,the tissue distribution information of hyperlipi-demia was collected through the BioGPS database,and the results were visualized by Cytoscape 3.9.1 software after data processing.Results Through network pharmacology analysis,69 active ingredients of hawthorn were obtained,of which 35 active ingredients were related to hawthorn in the treatment of hyperlipidemia.The 188 intersection genes of component-dis-ease target genes were well expressed in heart,liver,lung,whole blood,skeletal muscle,prostate and thyroid.There are 12 key targets,including serine/threonine protein kinase(AKT1),tumor necrosis factor(TNF)and interleukin(IL-6).KEGG enrichment analysis obtained 201 pathways,including lipid and atherosclerosis,fluid shear stress and atherosclerosis,and PI3K-Akt pathway.Molecular docking results showed that the main components of hawthorn had good binding ability with key targets.Conclusion Network pharmacology studies have shown that hawthorn treatment of hyperlipidemia is achieved through multi-component-multi-target-multi-pathway,providing a reference for the later study of hawthorn treatment of hyperlipidemia.
万方数据
维普
