Objective In this study,the feasibility of fused deposition molding(FDM)technology for the preparation of Acetaminophen(APAP)Tablets was studied,which provided experimental basis for the application of this technology in 3D printing of Acetaminophen Tablets.Methods Using hot melt extrusion(HME)technology and the fused deposition modeling technology to prepare the molding tablets.During the screening process,the amount and types of excipients,were determined.Then the optimal prescription and process parameters were screened by orthogonal design.Finally the content de-termination,in vitro release,scanning electron microscope and thermogravimetric analysis were evaluated.Results The final optimized 3D printed APAP tablets prescription was APAP∶plasticized ethyl cellulose∶hypromellose∶triethyl citrate=25∶50∶25∶10,the optimized printing temperature was 160 ℃.The in vitro release rate of tablets was about 50％at 6 hour and was over 90％within 24 hours.Conclusion APAP tablets were successfully prepared.The resulting product appears a flat sur-face and the stacking of layers is relatively smooth.The tables has a slower in vitro release rate compared to APAP tables on the market.The active pharmaceutical ingredient is stable in content at the test temperature.
关键词
熔融沉积成型技术/3D打印/对乙酰氨基酚/制备工艺
Key words
Fused deposition molding technology/3D printing/Acetaminophen/Technology of preparation
维普
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