Effect of invigorating spleen and nourishing stomach on the level of tumor markers,immune function and long-term curative effect in elderly patients with advanced gastric cancer
Objective To explore the effects of invigorating the spleen and nourishing the stomach on the level of tumor markers,immune function and long-term efficacy in elderly patients with advanced gastric cancer.Methods 95 patients with advanced gastric cancer admitted to the gastroenterology department of our hospital from June 2019 to June 2022 were collected and randomly divided into control group(47 cases)and experimental group(48 cases).The control group was given FOLFOX4 regimen for chemotherapy,and the experimental group was given spleen-strengthening and stomach-nourishing method on the basis of the control group.Both groups were treated for 9 weeks.After treatment,TCM symptom scores,serum tumor markers,immune function indexes,gastrointestinal reactions and myelosuppression during treatment,and long-term sur-vival rates were compared between the two groups.Results After treatment,the clinical effective rate of experimental group was higher than that of control group(P＜0.05).After treatment,the scores of traditional Chinese medicine symptoms such as abdominal tightness,distention pain,poor appetite,loose stool and anesthesia in the 2 groups were reduced compared with be-fore treatment.Compared with the control group,the scores of all TCM symptoms in experimental groups were lower(P＜0.05).After treatment,CEA,CA12-5,CA19-9 and CA72-4 were decreased compared with before treatment.Compared with the con-trol group,CEA,CA12-5,CA19-9 and CA72-4 in experimental groups were lower(P＜0.05).After treatment,CD4+/CD8+and C3+increased,while IgG and IgM decreased in 2 groups compared with before treatment(P＜0.05).Compared with the control group,CD4+/CD8+and C3+in experimental groups were higher,while IgG and IgM were lower(P＜0.05).There was no signifi-cant difference in 6-month and 1-year survival rates between the two groups(P＞0.05).The 3-year survival rate of experimen-tal group was higher than that of control group(P＜0.05).Conclusion Invigorating spleen and nourishing stomach has signifi-cant effect in the treatment of elderly patients with advanced gastric cancer,which can improve immune function and downreg-ulate the level of tumor markers,and is suitable for clinical application.
Invigorating spleen and nourishing stomachElderly patients with advanced gastric cancerTumor markerImmune functionLong-term efficacy
万方数据
维普
