Analysis of the mechanism of safflower-achyranthes bidentata in treating oral submucous fibrosis based on network pharmacology
Objective To explore the therapeutic targets of safflower-achyranthes in oral submucous fibrosis(OSF)via network pharmacology and molecular docking technology.Methods Based on the network pharmacology approach,we obtained the active ingredients and targets of"Safflower"and"Achyranthes bidentata",as well as the disease targets of OSF.A PPI network of protein interactions was constructed using the STRING platform;Molecular docking analysis was per-formed between the key active ingredients and the core targets;And GO and KEGG enrichment analysis was performed on the intersection targets.Results The main active ingredients of safflower-achyranthes in OSF were found to be luteolin,ba-icalin,berberine,and coptisine,etc.;The main core targets are tumor necrosis factor,matrix metalloproteinase 9,mitogen ac-tivated protein kinase 3,hypoxia inducible factor 1α,etc.It mainly involves negative regulation of apoptosis,response to hy-poxia,positive regulation of MAPK cascade,as well as signaling pathways such as proteoglycans in cancer,mitogen activated protein kinase,interleukin-17,and C-type lectin receptor and other signaling pathways.The molecular docking results also showed that the active molecules have good binding power to the target genes.Conclusion The results showed that safflower-achyranthes might treat OSF through multi-component,multi-target,and multiple signaling pathways.
万方数据
维普
