Discussion of the development status,trend and enlightenment of organoids and organ-on-chips from the perspective of regulatory science of cosmetics
In recent years,new complex in vitro models such as organoids and organ-on-chips have emerged at the forefront of international technology and research,gradually being applied to drug and cosmetic research,development,and supervision while attracting considerable attention.This article briefly explains the basic concepts,development history,and technical characteristics of organoids and organ-on-chips.It then provides examples of their application in safety and effica-cy testing of cosmetic ingredients.Finally,combining domestic and international cosmetic regulations,it looks forward to fu-ture trends using organoids and organ-on-chips to improve the efficiency of cosmetic ingredient research and support regu-latory decision-making.Additionally,it proposes regulatory suggestions for the application of this type of new technology from a perspective of regulatory science with an aim to provide technical reserves for cosmetic regulation that aligns with China's situation and promote the transformation of innovative achievements in scientific research into practical regulatory tools.