Research progress on intestinal microorganisms regulated by licorice to improve drug-induced liver injury
Objective To summarize the mechanisms of licorice and its compound prescriptions regulating intestinal microbes to improve drug-induced liver injury(DILI)in recent years.Methods In the CNKI and PubMed databases,using licorice or licorice compound and liver injury and intestinal flora as keywords,the literature on licorice and its com-pound in relieving liver injury in recent years was screened,and the relationship between intestinal flora and intestinal flora was summarized.The relationship between DILI,licorice and the mechanism of DILI relief by regulating gut microbiota.Re-suIts The liver induced by drugs can lead to abnormal composition of intestinal flora,intestinal barrier damage,and trans-location of bacteria and their metabolites,and abnormal intestinal flora may aggravate liver injury through multiple channels.The components and compounds in licorice can improve DILI by regulating the composition of intestinal flora,restoring the intestinal barrier,anti-inflammation,and enhancing the immune mechanism.Conclusion Licorice and its compound can alleviate drug DILI by regulating intestinal flora,and provide reference for expanding the research and clinical treatment of drug-induced liver injury in traditional Chinese medicine.
国家科技期刊平台
NSTL
万方数据
