Objective To evaluate the protective effect of flavonoids from Suaeda glauca(SGF)on mice with liver fibrosis induced by carbon tetrachloride.Methods The qualitative analysis of components in SGF was carried out by a LC-MS/MS method.The mouse liver fibrosis model was induced by carbon tetrachloride.The serum levels of lipid,liver function,appearance and pathological changes of liver,the mRNA levels of matrix metallopeptidase 9(MMP-9),tissue inhibitor of metalloproteinases 1(TIMP-1)and collagen 1α1(Col1α1)were selected to clarity the effectiveness of SGF on liver fibrosis and the possible mechanism in mice.Results Thirty-five compounds were preliminarily identified in SGF.SGF effectively lowered the serum levels of lipid,improved the liver appearance,alleviated the pathological changes of liver,restored the liver function,down-regulated the mRNA levels of TIMP-1 and Col1α1,up-regulated the mRNA level of MMP-9 in mice induced by carbon tetrachloride.Conclusion SGF alleviates carbon tetrachloride-induced liver fibrosis in mice.
关键词
碱蓬黄酮/四氯化碳/肝纤维化/基质金属蛋白酶-9/金属蛋白酶组织抑制剂-1
Key words
Flavonoids from Suaeda glauca/Carbon tetrachloride/Liver fibrosis/MMP-9/TIMP-1
维普
万方数据