Literature case analysis of acute generalized exanthematous pustulosis in pregnancy induced by drugs
Objective To explore the characteristics of drugs inducing acute generalized exanthematous pustulosis during pregnancy,and the clinical features,disease course and outcomes of the disease.Methods The relevant databases including PubMed,EMBASE,Web of Science and four Chinese native databases were searched and literature on AGEP in pregnancy were reviewed.The information of patients[nationality,age,gestational course,history of allergy,history of psoriasis,causes,usage(drugs),time of onset,clinical manifestations and examinations,treatments and outcomes,skin biopsy results]were collected and descriptively analyzed.Results A total of 14 patients were included,2 in the first trimester,4 in the second trimester and 8 in the third trimester.The mean age was 32 years old(from 23 to 39 years old).Apart from 1 case was triggered by vaccine,the other 13 cases were all considered to be caused by drugs[7(53.85%)for antibiotics and 1(7.69%)for each of mifepristone,labetalol,omeprazole,hydroxychloroquine,acetaminophen,phloroglucinol].The onset time ranged from hours to dozens of days.All patients were cured after 2～15 days.There're no statistical differences in onset time or recovery duration among different stages of pregnancy or routes of administration(P>0.05).Conclusion AGEP in pregnancy could be induced by drugs in very common use,and mostly triggered within 3 days with typical clinical manifestations.With suspected drugs stopped and symptomatic/supportive treatments,the recovery was always good.
Acute generalized exanthematous pustulosisPregnancyAntibioticsLiterature case analysis
万方数据
维普
