Low-dose Danning Tablets protect gallbladder function after laparoscopic combined choledochoscopy lithotripsy by reducing oxidative stress in the body
Objective The purpose of this study is to examine the influence of low-dose Danning Tablets on gallbladder functionality post laparoscopic combined choledochoscopy lithotripsy(LRCL).Methods A total of 108 participants with gallbladder stones who underwent LRCL were randomly allocated into two groups,with 54 participants in each group.The observation group received treatment with low-dose Danning Tablets,while the control group received a placebo.Changes in serum levels of NO,MDA,SOD,and GSH were assessed after 3 months of treatment,and gallbladder function indicators,including stone recurrence rate,gallbladder contraction rate,gallbladder wall thickness,and plasma cholecystokinin(CCK)levels,were measured at the 12th and 24th months.Results After 3 months of treatment,the observation group exhibited significantly lower levels of MDA compared to the control group,while demonstrating significantly higher levels of SOD and GSH(P<0.05).However,there were no significant differences in NO levels between the two groups.At the 12th and 24th months,the observation group displayed significantly higher gallbladder contraction rates and CCK levels compared to the control group(P<0.05).In addition,the gallbladder wall thickness of the observation group was significantly lower than that of the control group(P<0.05).Furthermore,the recurrence rate of gallbladder stones was significantly lower in the observation group than in the control group.Conclusion In conclusion,oral administration of low-dose Danning Tablets post LRCL can effectively diminish postoperative oxidative stress levels and significantly enhance gallbladder function,thereby reducing the recurrence rate of gallbladder stones.It serves as an effective preventive measure for gallbladder stone recurrence and promotes improved postoperative health indices among patients.
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