Research progress of m6A associated protein inhibitors
N6-methyladenosine(m6A)is a widespread transcriptional modification in organisms,which is mainly regulated by methyltransferase,demethylase and reading protein.It plays an important role in RNA processing,transport,translation and stability.In recent years,the abnormal expression of m6A associated proteins has been found in tumors,and the tumor progression can be regulated by changing the m6A modification level of target genes.Therefore,the treatment of m6A modification has broad prospects.m6A associated protein inhibitors are a class of compounds that can inhibit m6A methylation modification,which can be used to study the mechanism of m6A modification in gene expression regulation.In this paper,three key molecules of m6A and their relationship with disease were reviewed,and the latest research progress of small molecule inhibitors of these m6A associated proteins was summarized.
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