首页|原位水凝胶作为联合递药系统在肿瘤治疗中的研究进展

原位水凝胶作为联合递药系统在肿瘤治疗中的研究进展

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原位水凝胶因其具有生物相容性、环境敏感性、高稳定性、可注射性等优点,成了医药领域的研究热点。由于原位水凝胶独特的相转变性质,它能够在给药部位实现药物在局部的持续释放。此外,原位水凝胶还可以将多种治疗手段(如化疗、光热疗法、光动力疗法、基因疗法和免疫疗法等)结合使用,以实现肿瘤的联合治疗。本文综述了近年来原位水凝胶作为联合递药系统在肿瘤治疗中的研究进展和发展前景。
Research progress of in situ hydrogels as co-delivery system in tumor treatment
In situ hydrogels have become a hot research topic in the field of pharmaceuticals due to their biocompati-bility,environmental sensitivity,high stability and injectability.Due to the unique phase transition properties of in situ hydro-gels,it is possible to achieve sustained release of drugs locally at the site of administration.In addition,in situ hydrogels will also be able to combine various therapeutic means(e.g.,chemotherapy,photothermal therapy,photodynamic therapy,gene therapy,and immunotherapy,etc.)to achieve the combined treatment of tumors.This review focuses recent progress and de-velopment prospects of in situ hydrogels as co-delivery system in tumor treatment.

In situ hydrogelCombination therapyAntitumorDrug delivery system

刘梦丽、何东升、姜雷、涂家生

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中国药科大学药学院药用辅料及仿创药物研发评价中心,江苏南京 210009

国家药品监督管理局药物制剂及辅料研究与评价重点实验室,江苏南京 210009

原位水凝胶 联合治疗 抗肿瘤 药物递送系统

国家自然科学基金青年项目江苏省自然科学基金青年项目

82003293BK20180553

2024

药学研究
山东省药品检验所 山东省药学会

药学研究

CSTPCD
影响因子:0.653
ISSN:2095-5375
年,卷(期):2024.43(9)