首页|逆境条件下药用植物酚酸类物质"内外大循环"代谢及作用机制探讨

逆境条件下药用植物酚酸类物质"内外大循环"代谢及作用机制探讨

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逆境胁迫是植物进化过程中必不可少的驱动因子,关于植物应对逆境胁迫的适应机制研究日趋深入.植物体内的次生代谢物含量中酚酸类大约占到30%,它具有抗微生物、抗氧化、抗细胞毒性和抗炎的作用,是植物抗逆胁迫过程中的主要"功臣",也是药用植物发挥临床药效的重要物质基础.前期研究发现,连作条件下丹参植株体内的酚酸类成分含量增加,根际的邻苯二甲酸、苯甲酸等物质能够促进立枯丝核菌增殖,致使连作丹参木质素合成增加,提升植物对病原菌侵染的防御能力.故而本研究对酚酸类次生代谢物在药用植物体内合成以及体外代谢的"全链条"代谢途径进行综合探讨,总结酚酸类次生代谢物合成及分泌的全过程,以期为药用植物抗逆、抗病应答研究提供理论支撑.
Study on Metabolism in'Internal and External Circulation'and Action Mechanism of Phenolic Acids in Medicinal Plants under Adverse Stress
Adverse stresses are indispensable driving factors in plant evolution,and researches on the a-daptive mechanisms of plants to adverse stresses are gradually deepened.Phenolic acids account for about 30%of plant secondary metabolites,and have anti-microbial,anti-oxidant,anti-cytotoxic and anti-inflammatory effects,so they are the main contributors to the process of plant adversity stress resistance and the important material basis for the clinical efficacy of medicinal plants.Previous studies indicated that the content of phenol-ic acids in Salvia divinorum plants increased under continuous cropping conditions,and rhizosphere phthalic acid and benzoic acid could promote the proliferation of Rickettsia sp.,resulting in the increase of lignin syn-thesis in continuous cropping S.divinorum,and enhancing plant defense against phytopathogens.This study discussed the whole chain of metabolic pathways of phenolic acids synthesized in vivo and metabolized in vitro,and summarized the whole process of phenolic acids synthesis and secretion,hoping to provide theoretical sup-ports for medicinal plants response to adversity and disease resistance.

Phenolic acidsMedicinal plantsAdversity stressSynthetic regulationRoot exudatesRhizosphere microorganisms

付心雨、鞠吉东、孟缘、周冰谦、卢恒、王晓、郭兰萍、刘伟

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山东中医药大学,山东济南 250355

齐鲁工业大学(山东省科学院)山东省分析测试中心,山东济南 250014

齐鲁工业大学(山东省科学院)药学院,山东济南 250014

中国中医科学院中药资源中心,北京 100700

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酚酸 药用植物 逆境胁迫 合成调控 根系分泌物 根际微生物

国家自然科学基金面上项目国家现代农业产业技术体系项目中央本级重大增减支项目山东省重点研发计划项目齐鲁工业大学(山东省科学院)科教产融合创新试点工程项目齐鲁工业大学(山东省科学院)科教产融合创新试点工程项目

82173917CARS-2120603022021ZDSYS122023PYI0042022PX093

2024

山东农业科学
山东省农业科学院,山东农学会,山东农业大学

山东农业科学

CSTPCD北大核心
影响因子:0.578
ISSN:1001-4942
年,卷(期):2024.56(9)