Correlations between thyroid hormone level and cognitive and affective disorders in patients with cerebral small vessel disease
Objective To investigate the correlations between serum thyroid hormone level and cognitive and affec-tive disorders in patients with cerebral small vessel disease(CSVD).Methods A total of 216 patients with CSVD were selected.Serum thyroid hormone level was detected.Cognitive function was assessed using the Montreal Cognitive Assess-ment(MoCA).Affective function was assessed using 24-item Hamilton Rating Scale for Depression(HAMD24)and Hamil-ton Anxiety Scale 14 items(HAMA14).According to the results,the patients were divided into the cognitive impairment group and non-cognitive impairment group,the affective disorder group and non-affective disorder group.The correlations between thyroid hormone level and cognitive impairment and affective disorders in patients with CSVD were analyzed by univariate and multivariate Logistic regression.Results According to MoCA score,216 CSVD patients were divided into cognitive impairment group(144 cases)and non-cognitive impairment group(72 cases).There were significant differ-ences in age,years of education,glycosylated hemoglobin,high-density lipoprotein,homocysteine,thyroid-stimulating hormone and free T3 levels between cognitive impairment group and non-cognitive impairment group(all P<0.05).After adjusting the influence of confounders by multivariate Logistic regression analysis,it was found that age,glycosylated he-moglobin,homocysteine and thyroid-stimulating hormone levels were risk factors for cognitive impairment in CSVD pa-tients(all P<0.05).Years of education>12 years,high-density lipoprotein and free T3 levels were protective factors for cognitive impairment in CSVD patients(all P<0.05).According to the scores of HAMA14 and HAMD24,216 CSVD patients were divided into affective disorder group(110 cases)and non-affective disorder group(106 cases).There were signifi-cant differences in gender,years of education,uric acid,free T3 and free T4 levels between the affective disorder group and the non-affective disorder group(all P<0.05).After adjusting the influence of confounders by multivariate Logistic re-gression analysis,it was found that high free T4 level was a risk factor for affective disorder in CSVD patients(P<0.05).Male,7-12 years of education,>12 years of education,and low free T3 level were protective factors for affective disorders in CSVD patients(all P<0.05).Conclusion Serum thyroid hormone levels in CSVD patients are associated with cogni-tive impairment and affective disorder,among which increased thyroid-stimulating hormone level is a risk factor for cogni-tive impairment in CSVD patients,and elevated free T4 level is a risk factor for affective disorder in CSVD patients.
cerebral small vessel diseasethyroid hormonecognitive impairmentaffective disorder
万方数据
维普
