Objective To investigate the relationships between serum soluble signal peptide-CUB-epithelial growth factor domain-containing protein 1(SCUBE1),lipoprotein phospholipase A2(Lp-PLA2)and coronary artery high throm-bus burden(HTB)in patients with acute ST-segment elevation myocardial infarction(STEMI).Methods Totally 126 acute STEMI patients(acute STEMI group)were divided into the HTB group(57 cases)and non-HTB group(69 cases)according to thrombus grading,and 87 healthy people with physical examination in the same period were selected as the control group.Serum SCUBE1 and Lp-PLA2 levels were measured by enzyme-linked immunosorbent assay.Multifactorial logistic regression was used to analyze the influencing factors for coronary HTB in patients with acute STEMI,and receiv-er operating characteristic(ROC)curve was used to evaluate the the predictive value of serum SCUBE1 and Lp-PLA2 lev-els on coronary HTB in patients with acute STEMI.Results Serum SCUBE1 and Lp-PLA2 levels were higher in the acute STEMI group than the control group(both P<0.05).The age,smoking proportion,low-density lipoprotein choles-terol,white blood cell count,SCUBE1,and Lp-PLA2 levels of patients with HTB were higher than those of patients with-out HTB(all P<0.05),and there were no significant differences in gender,underlying diseases,culprit vessels,Gensi-ni scores,or left ventricular ejection fractions between the two groups(all P>0.05).Multifactorial Logistic regression analysis showed that increased age,smoking,and elevated SCUBE1 and Lp-PLA2 were independent risk factors for coro-nary HTB in patients with acute STEMI(all P<0.05).ROC curve analysis showed that the area under the curve of serum SCUBE1 and Lp-PLA2 levels in predicting the coronary HTB in patients with acute STEMI was 0.874,which was greater than that of serum SCUBE1 and Lp-PLA2 levels individually(0.794 and 0.791)(both P<0.05).Conclusion Elevat-ed serum SCUBE1 and Lp-PLA2 levels in patients with acute STEMI are closely associated with coronary HTB,and the combined detection of serum SCUBE1 and Lp-PLA2 levels has high predictive value for coronary HTB in patients with acute STEMI.
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