首页|血清SCUBE1、Lp-PLA2水平与急性STEMI患者冠状动脉高血栓负荷的关系

血清SCUBE1、Lp-PLA2水平与急性STEMI患者冠状动脉高血栓负荷的关系

扫码查看
原文链接
  • 万方数据
  • 维普
目的 探讨血清可溶性信号肽-CUB-表皮生长因子样结构域蛋白1(SCUBE1)、脂蛋白磷脂酶A2(Lp-PLA2)与急性ST段抬高型心肌梗死(STEMI)患者冠状动脉高血栓负荷(HTB)的关系。方法 选取126例急性STEMI患者(急性STEMI组)，根据血栓分级分为HTB患者57例和非HTB患者69例;另选取87名健康体检者为对照组。用酶联免疫吸附法检测血清SCUBE1、Lp-PLA2;用多因素Logistic回归分析急性STEMI患者冠状动脉HTB的影响因素;用受试者工作特征(ROC)曲线评估血清SCUBE1、Lp-PLA2水平对急性STEMI患者冠状动脉HTB的预测价值。结果 急性STEMI组血清SCUBE1、Lp-PLA2水平高于对照组(P均<0。05)。HTB患者年龄、吸烟比例、低密度脂蛋白胆固醇、白细胞计数、SCUBE1、Lp-PLA2水平高于非HTB患者(P均<0。05)，两者性别、基础疾病、罪犯血管、Gensini评分、左室射血分数比较差异无统计学意义(P均>0。05)。多因素Logistic回归分析显示，年龄增加、吸烟和血清SCUBE1、Lp-PLA2水平升高为急性STEMI患者冠状动脉HTB的独立危险因素(P均<0。05)。ROC曲线分析显示，血清SCUBE1、Lp-PLA2水平联合预测急性STEMI患者冠状动脉HTB的曲线下面积为0。874，大于二者单独预测的0。794、0。791(P均<0。05)。结论 急性STEMI患者血清SCUBE1、Lp-PLA2水平升高与冠状动脉HTB密切相关，二者联合检测对急性STEMI患者冠状动脉HTB的预测价值较高。
Relationships between serum SCUBE1,Lp-PLA2 and coronary artery high thrombus burden in patients with acute STEMI
Objective To investigate the relationships between serum soluble signal peptide-CUB-epithelial growth factor domain-containing protein 1(SCUBE1),lipoprotein phospholipase A2(Lp-PLA2)and coronary artery high throm-bus burden(HTB)in patients with acute ST-segment elevation myocardial infarction(STEMI).Methods Totally 126 acute STEMI patients(acute STEMI group)were divided into the HTB group(57 cases)and non-HTB group(69 cases)according to thrombus grading,and 87 healthy people with physical examination in the same period were selected as the control group.Serum SCUBE1 and Lp-PLA2 levels were measured by enzyme-linked immunosorbent assay.Multifactorial logistic regression was used to analyze the influencing factors for coronary HTB in patients with acute STEMI,and receiv-er operating characteristic(ROC)curve was used to evaluate the the predictive value of serum SCUBE1 and Lp-PLA2 lev-els on coronary HTB in patients with acute STEMI.Results Serum SCUBE1 and Lp-PLA2 levels were higher in the acute STEMI group than the control group(both P<0.05).The age,smoking proportion,low-density lipoprotein choles-terol,white blood cell count,SCUBE1,and Lp-PLA2 levels of patients with HTB were higher than those of patients with-out HTB(all P<0.05),and there were no significant differences in gender,underlying diseases,culprit vessels,Gensi-ni scores,or left ventricular ejection fractions between the two groups(all P>0.05).Multifactorial Logistic regression analysis showed that increased age,smoking,and elevated SCUBE1 and Lp-PLA2 were independent risk factors for coro-nary HTB in patients with acute STEMI(all P<0.05).ROC curve analysis showed that the area under the curve of serum SCUBE1 and Lp-PLA2 levels in predicting the coronary HTB in patients with acute STEMI was 0.874,which was greater than that of serum SCUBE1 and Lp-PLA2 levels individually(0.794 and 0.791)(both P<0.05).Conclusion Elevat-ed serum SCUBE1 and Lp-PLA2 levels in patients with acute STEMI are closely associated with coronary HTB,and the combined detection of serum SCUBE1 and Lp-PLA2 levels has high predictive value for coronary HTB in patients with acute STEMI.

acute ST-segment elevation myocardial infarctionsoluble signal peptide-CUB-epithelial growth factor domain-containing protein 1lipoprotein phospholipase A2high thrombus burden

赵景宏、乔彦、张荣驿、邓建平、胡济麟

展开 >

川北医学院第二临床学院 南充市中心医院心内科,四川南充 637000

川北医学院第二临床学院 南充市中心医院内分泌科

急性ST段抬高型心肌梗死 可溶性信号肽-CUB-表皮生长因子样结构域蛋白1 脂蛋白磷脂酶A2 高血栓负荷

四川省基层卫生事业发展研究项目

SWFZ21-C-68

2024

10.3969/j.issn.1002-266X.2024.07.007

山东医药
山东卫生报刊社

山东医药

CSTPCD
影响因子：1.225
ISSN：1002-266X
年,卷(期)：2024.64(7)
  • 26