Objective To investigate the relationships between serum high-mobility group protein B1(HMGB1),hu-man β-defensin 2(hBD-2)and the development of occlusive bronchiolitis obliterans(BO)in children with adenovirus pneu-monia(AP)and its predictive value.Methods Totally 193 children with AP were selected,and the children with AP were divided into the BO group(58 cases)and the non-BO group(135 cases)according to whether BO occurred 3 months af-ter discharge.Serum HMGB1 and hBD-2 levels were measured by enzyme-linked immunosorbent assay.Univariate and Mul-tifactorial Logistic regression analyses were used to analyze the factors influencing the development of BO in children with AP;the receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum HMGB1 and hBD-2 for BO in AP children.Results The age of the BO group was younger than that of the non-BO group,the duration of fever was longer than that of the non-BO group,the proportions of hypoxemia and mechanical ventilation and the white blood cell count,platelet count,C-reactive protein,procalcitonin,HMGB1,and hBD-2 were higher than those of the non-BO group(all P<0.05).Multifactorial Logistic regression model analysis showed that hypoxemia,mechanical ventilation and elevated HMGB1 and hBD-2 were independent risk factors for the development of BO in children with AP(all P<0.05).ROC curve analysis showed that the area under the curve of serum HMGB1 and hBD-2 in predicting the development of BO in children with AP was 0.818,which was greater than that of serum HMGB1 and hBD-2 alone(0.739 and 0.726)(both P<0.05).Conclusion Elevated serum HMGB1 and hBD-2 levels are risk factors for BO in children with AP,and the combined detection of serum HMGB1 and hBD-2 levels has high predictive value for the development of BO in children with AP.
关键词
腺病毒肺炎/闭塞性细支气管炎/高迁移率族蛋白B1/人β防御素2
Key words
adenovirus pneumonia/bronchiolitis obliterans/high-mobility group protein B1/human β-defensin 2
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