Relationships between serum PGC-1α and A1AT levels and type 2 diabetes mellitus combined with non-alcoholic fatty liver disease
Objective To investigate the relationships between serum peroxisome proliferator-activated receptor γ coactivator-1α(PGC-1α)and α1-antitrypsin(A1AT)levels and type 2 diabetes mellitus(T2DM)combined with non-al-coholic fatty liver disease(NAFLD).Methods Totally 184 patients with T2DM(T2DM group)and another 60 healthy volunteers for physical examination during the same period(control group)were selected,and the patients with T2DM were classified into the NAFLD group(95 patients)and the non-NAFLD group(89 patients)according to whether they had NAFLD or not.Serum PGC-1α and A1AT levels were measured by enzyme-linked immunosorbent assay.Factors af-fecting T2DM combined with NAFLD were analyzed using multifactorial Logistic regression,and the predictive value of se-rum PGC-1α and A1AT levels for T2DM combined with NAFLD was analyzed using receiver operating characteristic(ROC)curves.Results Compared with the control group,serum PGC-1α and A1AT levels were reduced in the T2DM group(both P<0.05).Compared with the non-NAFLD group,serum PGC-1α and A1AT levels were reduced in the NAFLD group(both P<0.05).Increased body mass index,prolonged duration of T2DM,hypertension,and elevated total of cholesterol,triacylglycerol,low-density lipoprotein cholesterol,aspartate aminotransferase,and alanine transaminase were independent risk factors for NAFLD in combination with T2DM,and elevated high-density lipoprotein cholesterol,PGC-1α,and A1AT were independent protective factors(all P<0.05).The area under the curve(AUC)of serum PGC-1α and A1AT levels combined in predicting T2DM combined with NAFLD was 0.885,which was greater than that of se-rum PGC-1α and A1AT levels alone,which were 0.788 and 0.786(both P<0.05).Conclusion Reduced serum PGC-1α and A1AT levels are closely associated with T2DM combined with NAFLD,and the combination of serum PGC-1α and A1AT levels has a high predictive value for T2DM combined with NAFLD.
万方数据
维普
