Changes in levels of serum MCP-1 and 5-HT in patients with obstructive sleep apnea hypopnea syndrome
Objective To investigate the changes in levels of serum monocyte chemotactic protein-1(MCP-1)and 5-hydroxytryptamine(5-HT)in patients with obstructive sleep apnea hypopnea syndrome(OSAHS)and their clinical sig-nificance.Methods Totally 107 OSAHS patients(OSAHS group)were selected and divided into the MCI group(43 cases)and NMCI group(64 cases)according to whether mild cognitive impairment(MCI)occurred or not,and 48 healthy volunteers with medical checkups in the same period(control group)were selected.Serum MCP-1 and 5-HT levels were measured by ELISA.Factors affecting the occurrence of MCI in OSAHS patients were analyzed by multifactorial Logistic regression,and the predictive value of serum MCP-1 and 5-HT levels for MCI in OSAHS patients was analyzed by receiver operating characteristic(ROC)curve.Results Compared with the control group,the serum MCP-1 level increased and 5-HT level decreased in the OSAHS group(both P<0.05).The incidence of MCI in 107 OSAHS patients was 40.19%(43/107).Compared with the NMCI group,the serum MCP-1 level increased and 5-HT level decreased in the MCI group(both P<0.05).Increasing age,severity of disease and elevated MCP-1 were independent risk factors for the development of MCI in patients with OSAHS,and elevated 5-HT was an independent protective factor(all P<0.05).The area under the curve of serum MCP-1 and 5-HT in predicting MCI in patients with OSAHS was 0.906,which was greater than that(0.805,0.828)of serum MCP-1 and 5-HT alone(both P<0.05).Conclusion The elevated serum MCP-1 level and re-duced 5-HT level in OSAHS patients are closely associated with MCI,and the combination detection of serum MCP-1 and 5-HT has a high predictive value for the occurrence of MCI in OSAHS patients.
万方数据
维普
