Changes in level of TXNIP and sCD36 in patients with polycystic ovary syndrome and their clinical significance
Objective To investigate the changes in levels of serum thioredoxin-interacting protein(TXNIP)and soluble cluster of differentiation 36(sCD36)in patients with polycystic ovary syndrome(PCOS)and their clinical signifi-cance.Methods Totally 124 patients with PCOS were selected as the PCOS group,and another 117 healthy women with physical examination during the same period were selected as the control group.Glycolipid metabolic indices[fasting blood glucose(FPG),fasting insulin(FINS),total cholesterol(TC),triacylglycerol(TG),high-density lipoprotein cho-lesterol(HDL-C),and low-density lipoprotein cholesterol(LDL-C)]and homeostasis model assessment of insulin resis-tance(HOMA-IR)were collected from all the study subjects,and the levels of serum TXNIP,and sCD36 were measured by enzyme-linked immunosorbent assay.Pearson/Spearman correlation analysis was used to analyze the correlation of se-rum TXNIP and sCD36 levels with glucose-lipid metabolism indexes and HOMA-IR in patients with PCOS,multifactorial Logistic regression analysis was used to analyze the relationship between serum TXNIP and sCD36 levels and PCOS,and receiver operating characteristic(ROC)curves were used to analyze the diagnostic value of serum TXNIP and sCD36 lev-els for PCOS.Results Compared with the control group,the PCOS group had increased levels of FPG,FINS,TC,TG,LDL-C,HOMA-IR,TXNIP,and sCD36,and decreased level of HDL-C(all P<0.05).Pearson/Spearman correlation analysis showed that serum TXNIP and sCD36 levels were positively correlated with FPG,FINS,TC,TG,LDL-C,and HOMA-IR in patients with PCOS(r=0.546,0.563,0.605,0.580,0.565,0.662 and 0.593,0.525,0.616,0.513,0.598,0.683,respectively;all P<0.05)and were negatively correlated with HDL-C(r=-0.551,-0.545,respective-ly,all P<0.05).Multifactorial Logistic regression analysis showed that elevated serum TXNIP(OR=1.047,95%CI:1.017 to 1.078)and sCD36(OR=1.475,95%CI:1.165 to 1.868)levels were independent risk factors for PCOS after correction for glycolipid metabolism indexes and HOMA-IR(all P<0.05).ROC curve analysis showed that the area under the curve(AUC)of combination of serum TXNIP and sCD36 levels in the diagnosis of PCOS(AUC=0.914,95%CI:0.872 to 0.946)was greater than that of serum TXNIP(AUC=0.822,95%CI:0.768 to 0.868)and sCD36(AUC= 0.811,the 95%CI:0.755 to 0.858)alone(both P<0.05).Conclusion Elevated serum TXNIP and sCD36 levels in patients with PCOS are associated with disorders of glycolipid metabolism and IR,and the combination detection of serum TXNIP and sCD36 levels has a high diagnostic value for PCOS.
万方数据
维普
