Comparative analysis of rotavirus infection in children with diarrhea before and after COVID-19 outbreak
Objective To analyze and compare the incidence of rotavirus(RV)infection in children with diarrhea before and after the COVID-19 outbreak.Methods A total of 5 793 children with diarrhea admitted to the First Affiliat-ed Hospital of Xi'an Medical University from January 2017 to December 2022 were selected.The period from January 2017 to January 2020 was defined as the time before COVID-19 epidemic,and the period from January 2020 to December 2022 was defined as the time after COVID-19 epidemic.RV infection rate of children with diarrhea before and after the COVID-19 outbreak was compared.Results There were 881(25.29%)and 587(25.41%)cases of RV infection in di-arrheal children before and after COVID-19 outbreak,respectively.There was no significant difference in RV infection in diarrheal children before and after COVID-19 outbreak(P>0.05).There was no significant difference in RV infection rate in children with diarrhea of different genders before and after COVID-19 outbreak(P>0.05).The age groups with the highest RV infection rate in children with diarrhea before COVID-19 outbreak were≥1 to<2 years old,7 to 12 months old,and≥2 to<3 years old,and the age groups with the highest RV infection rate after COVID-19 outbreak were≥1 to<2 years old,≥2 to<3 years old,and 7 to 12 months old,respectively.There were significant differences in RV infection in children with diarrhea in different ages before and after COVID-19 outbreak(all P<0.05).The months with high inci-dence of RV infection in children with diarrhea before COVID-19 outbreak were December,January and November each year,and the months with high incidence of RV infection in children with diarrhea after COVID-19 outbreak were January,December and February each year,respectively.There were statistically significant differences in RV infection in children with diarrhea in different months before and after COVID-19 outbreak(all P<0.05).Conclusions Although the number of children with diarrhea and RV infection drops significantly after COVID-19,RV infection is still the main cause of diar-rhea in children.Gender is not an influential factor in RV infection in children with diarrhea.The age of high incidence of RV infection in children with diarrhea is less than 3 years old.In addition to autumn and winter seasons,RV infection may also be high in spring,and RV screening in non-RV season should be vigilant.