Relationship between Mfn 2 polymorphisms and susceptibility to overweight/obesity in Fuzhou Han population
Objective To investigate the relationships between mitofusin-2(Mfn 2)gene polymorphism and suscep-tibility to overweight/obesity in Han population of Fuzhou.Methods A total of 198 healthy subjects of Han nationality in Fuzhou were selected,of whom 104 were of normal body weight and 94 were overweight/obese.Fasting venous blood was collected and the genotypes of rs2295281 locus of Mfn2 gene were detected by Sanger sequencing.The frequency of gene loci and genotype were counted.After adjusting the confounding factors,the relationships between different geno-types and susceptibility to overweight/obesity were analyzed by unconditioned Logistic regression model.Further stratifica-tion by sex was conducted to analyze the relationships between different genotypes and overweight/obesity susceptibility in male and female populations.Results There were three genotypes(namely CT,TT,and CC)in the rs2295281 site of Mfn2 gene,including 78 cases of CC genotype,88 cases of CT genotype and 32 cases of TT genotype.The frequency of C allele was 61.62%and the frequency of the T allele was 38.38%.The results of the Logistic-regression analysis showed that,the T allele at the rs2295281 locus of the Mfn 2 gene had an increased risk of developing overweight/obesity in com-parison with the C allele(P=0.019,OR=1.688,95%CI 1.088-2.618),the TT genotype had an increased risk in com-parison with the CC genotype(P=0.018,OR=3.099,95%CI 1.214-7.909),the TT genotype also had an increased risk in comparison with CC+CT genotype(P=0.032,OR=2.572,95%CI 1.086-6.089).Stratified statistics based on gen-der found that,in males,T allele was associated with an increased risk of overweight/obesity in comparison with C allele(P=0.043,OR=1.900,95%CI 1.022-3.533),CT genotype was associated with an increased risk in comparison with CC genotype(P=0.027,OR=2.803,OR=2.803),and CT+TT genotype had a higher risk than CC genotype(P=0.02,OR=2.784,95%CI 1.178-6.584);in females,TT genotype was associated with an increased risk of overweight/obesity in comparison with CC+CT genotype(P=0.014,OR=4.683,95%CI 1.366 to 16.047).Conclusions There is an obvi-ous correlation between the gene distribution frequency of the rs2295281 locus of Mfn 2 gene and the susceptibility to over-weight/obesity.The T allele may increase the risk,and men with CT gene and women with TT gene can have diet and exer-cise intervention as early as possible.
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