Changes in levels of serum HMGB1 in patients with liver cirrhosis and its correlation with intestinal mucosal permeability
Objective To observe the changes in levels of serum high-mobility group protein B1(HMGB1)level and intestinal mucosal permeability(IP)-related indicators[D-lactic acid(D-lac),diamine oxidase(DAO),and endotox-in(ET)]in patients with liver cirrhosis,and to analyze the correlations between the level of serum HMGB1 and IP-related indicators to clarify the relationship between the level of serum HMGB1 and the IP of patients.Methods Sixty-three pa-tients with liver cirrhosis were enrolled.According to the Child-Pugh score,the patients were divided into the CP-A group(n=16),CP-B group(n=32)and CP-C group(n=15);33 cases of healthy people who underwent physical examination in the same period were used as the control group.The serum levels of HMGB1,ET,DAO and D-lac were detected by ELI-SA.The correlation between serum HMGB1,IP-related indicators and Child-Pugh classification,and the correlation be-tween serum HMGB1 and IP-related indicators in patients with liver cirrhosis were analyzed.Results The levels of HMGB1,ET,DAO and D-lac in the CP-A,CP-B and CP-C groups were higher than those in the control group,the levels of HMGB1,D-lac and ET in the CP-C group were higher than those in the CP-A group,and the levels of HMGB1 and ET in the CP-B group were higher than those in the CP-A group(all P<0.05).Serum HMGB1 was positively correlated with IP-related indicators ET,DAO and D-lac(r=0.371,0.854,0.623,all P<0.05).The serum levels of HMGB1,ET,DAO and D-lac in patients with liver cirrhosis were positively correlated with Child-Pugh classification(r=0.356,0.272,0.301 and 0.382,respectively,all P<0.05).Conclusion The serum HMGB1 level in patients with liver cir-rhosis increases,and IP increases,and they change more significantly with the severity of the disease;there is a positive correlation between the serum HMGB1 level and the patients'IP.
high-mobility group protein B1intestinal permeabilityD-lactic aciddiamine oxidaseendotoxinliver cirrhosis
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