Expression changes of AIP1 and EDIL3 in non-small-cell lung cancer tissues
Objective To investigate the changes in the expression levels of apoptosis signal-regulating kinase 1-in-teracting protein 1(AIP1)and epidermal growth factor-like repeats and discoidin I-like domains 3(EDIL3)in non-small-cell lung cancer(NSCLC)tissues,and to analyze their relationships with microvascular density(MVD),clinical and path-ological features,and prognosis in order to provide new intervention targets for targeted treatment of NSCLC.Methods Totally 155 cases of NSCLC patients were included,and the AIP1 and EDIL3 proteins in cancer tissues and adjacent can-cer tissues were detected by immunohistochemical method,and the MVD in cancer tissues was detected by Weidner meth-od.We compared the MVD values of NSCLC patients with different AIP1 and EDIL3 expression and the expression levels of AIP1 and EDIL3 in the cancer tissues of NSCLC patients with different clinical and pathological characteristics.The sur-vival situation of NSCLC patients with different AIP1 and EDIL3 expression levels was analyzed by Kaplan-Meier survival curve,and the influencing factors for the prognosis of NSCLC patients were analyzed by multivariate Cox regression.Re-sults Compared with the adjacent tissues,the positive expression rate of EDIL3 was higher and the positive expression rate of AIP1 was lower in the cancer tissues(both P<0.05).Significant differences were found in the positive expression rates of AIP1 and EDIL3 proteins in cancer tissues of NSCLC patients with different degrees of differentiation,lymph node metastasis,tumor diameter,and TNM staging(all P<0.05).The MVD value of cancer tissue in NSCLC patients with AIP1 positive expression was lower than that in AIP1 negative expression patients(P<0.05).The MVD value of cancer tis-sue in NSCLC patients with positive expression of EDIL3 was higher than that in patients with negative expression of EDIL3(P<0.05).The 3-year overall survival(OS)rate of NSCLC patients with positive expression of EDIL3 was lower than that of patients with negative expression of EDIL3(P<0.05),and NSCLC patients with AIP1 positive expression had higher 3-year OS rate than those with AIP1 negative expression(P<0.05).Lymph node metastasis,TNM stage IIIA,and positive expression of EDIL3 were risk factors for poor prognosis in NSCLC patients(all P<0.05),and positive expression of AIP1 was protective factor(P<0.05).Conclusions The positive expression rate of AIP1 decreases and the positive expres-sion rate of EDIL3 increases in NSCLC cancer tissues.The positive expression rates of AIP1 and EDIL3 in the cancer tis-sues are related to MVD,differentiation degree,lymph node metastasis,tumor diameter,and TNM staging,and are influ-encing factors for the poor prognosis of NSCLC.
apoptosis signal-regulating kinase 1-interacting protein 1epidermal growth factor-like repeats and dis-coidin I-like domains 3microvessel densitynon-small-cell lung cancer
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