Risk factors for pneumonia after nosocomial infection of SARS-CoV-2 in patients hospitalized for other diseases
Objective To analyze risk factors for pneumonia after nosocomial infection of novel coronavirus(SARS-CoV-2)in patients hospitalized for other diseases.Methods Totally 275 hospitalized patients for other diseases were di-vided into the pneumonia group(n=68)and non-pneumonia group(n=207)according to the development of pneumonia af-ter nosocomial infection of SARS-CoV-2,the clinical data of the patients were collected,and binary Logistic regression analysis was used to analyze the risk factors for pneumonia after SARS-CoV-2 infection in patients.Results Compared with the non-pneumonia group,patients in the pneumonia group were older,had a higher proportion of males,had higher proportions of hypertension,diabetes,cardiovascular and cerebrovascular diseases,nervous system diseases,chronic ob-structive pulmonary diseases,anemia,malnutrition,nasopharyngeal carcinomas and liver differentiated embryomas(all P<0.05).Compared with the non-pneumonia group,the red blood cell distribution width,white blood cell count and neutro-phils were higher,the serum levels of urea,glucose,alanine aminotransferase,aspartate aminotransferase,total biliru-bin,γ-glutamyl transpeptidase,alkaline phosphatase,fibrinogen and D-dimer were higher,the levels of prothrombin time and activated partial thromboplastin time were longer,the red blood cell count,hematocrit,hemoglobin,lymphocytes,eo-sinophils and basophils were lower,and the serum levels of calcium,total protein,albumin and cholinesterase were lower in the pneumonia group(all P<0.05).Increased age,male gender,prolonged prothrombin time,decreased percentage of basophils,shortened activated partial thromboplastin time and decreased level of serum total protein were risk factors for pneumonia(OR=1.037,5.383,115.786,0.155,0.884,and 0.941,respectively;all P<0.05).Conclusion Pa-tients hospitalized for other diseases with older age,male gender,longer prothrombin time,a lower percentage of baso-phils,shorter activated partial thromboplastin time and a lower serum total protein level are more likely to develop pneumo-nia after SARS-CoV-2 infection.
nosocomial infectionpneumoniasecondary pneumoniaSARS-CoV-2agegenderprothrom-binpercentage of basophilsalbumin
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