Diagnostic value of Aspergillus-specific IgM and IgG antibody levels in patients with pulmonary tuberculosis complicated with chronic pulmonary aspergillosis
Objective To evaluate the diagnostic value of Aspergillus-specific IgM and IgG antibody levels in pa-tients with pulmonary tuberculosis(PTB)complicated with chronic pulmonary aspergillosis(CPA).Methods Totally 200 patients with PTB were selected and divided into the CPA group(21 cases)and non-CPA group(179 cases)according to whether they had CPA.The levels of Aspergillus-specific IgM and IgG antibodies were detected,and the clinical data were collected.Multi-factor Logistic regression analysis was performed to identify the factors contributing to CPA in PTB patients.The value of Aspergillus-specific IgM and IgG antibodies in diagnosing patients with PTB complicated with CPA was analyzed using receiver operating characteristic curve.Results The levels of serum Aspergillus-specific IgM and IgG antibodies in the CPA group were higher than those in the non-CPA group(both P＜0.05).Pulmonary cavity,chronic obstructive pulmonary disease,bronchiectasis,high level of Aspergillus-specific IgM antibody and high level of Aspergil-lus-specific IgG antibody were risk factors for CPA in PTB patients(all P＜0.05).The area under the curve of Aspergillus-specific IgM antibody and Aspergillus-specific IgG antibody in diagnosing PTB complicated with CPA was 0.793 and 0.666,respectively.The area under the curve of them combined in diagnosing PTB complicated with CPA was 0.873,which was higher than that of Aspergillus-specific IgM antibody alone(P＜0.05),but was not significantly different from that of Aspergillus-specific IgG antibody(P＞0.05).Conclusions The levels of serum Aspergillus-specific IgG and IgM antibodies increase in patients with PTB complicated with CPA.Aspergillus-specific IgG antibodies are of high value in the diagnosis of PTB complicated with CPA.The combined detection of Aspergillus-specific IgG and IgM antibodies is helpful for the diagnosis of PTB complicated with CPA.
tuberculosischronic pulmonary aspergillosisAspergillus-specific IgM antibodyAspergillus-specif-ic IgG antibodydiagnostic value
万方数据
维普
