Relationships between platelet morphological parameters and severity of coronary lesions and prognosis in patients with acute coronary syndrome
Objective To investigate the relationships between platelet morphology parameters and the severity of coronary lesions and prognosis in patients with acute coronary syndrome(ACS).Methods Totally 123 patients with ACS(ACS group)and 50 physically examined healthy people in the same period(control group)were selected,and the patients with ACS were divided into the mild coronary artery lesion group(38 cases),moderate coronary artery lesion group(49 cases),and severe coronary artery lesion group(36 cases)based on the Gensini score,and the prognosis of pa-tients at 1 year after percutaneous coronary intervention was analyzed.Platelet morphological parameters[platelet distribu-tion width(PDW),mean platelet volume(MPV)and platelet-large cell ratio(P-LCR)]were measured by a fully automat-ed hematology analyzer.The correlation between platelet morphology parameters and Gensini score in ACS patients was an-alyzed by Spearman's correlation,the factors of poor prognosis in ACS patients were analyzed by Logistic regression,and the value of platelet morphology parameters in assessing the poor prognosis of ACS patients was analyzed by receiver operat-ing characteristic(ROC)curve.Results Compared with the control group,MPV,PDW,and P-LCR were elevated in the ACS group(all P＜0.05).MPV,PDW,and P-LCR increased sequentially in the mild,moderate,and severe coronary lesion groups(all P＜0.05).MPV,PDW,and P-LCR were positively correlated with Gensini scores in ACS patients(rs=0.778,0.800,and 0.761,respectively;all P＜0.05).At 1-year follow-up,the incidence of poor prognosis was 29.27%(36/123)in 123 patients with ACS.Killip classification≥Ⅱ,increased Gensini score,and elevated MPV,PDW,and P-LCR were independent risk factors for poor prognosis in patients with ACS(all P＜0.05).The area under the curve of MPV,PDW,and P-LCR combined in assessment of poor prognosis in patients with ACS was 0.924,which was greater than that of MPV,PDW,and P-LCR alone,which was 0.771,0.765,and 0.777(all P＜0.05).Conclusions Elevat-ed MPV,PDW,and P-LCR in patients with ACS are associated with increased degree of coronary artery disease and poor prognosis,and the combined detection of MPV,PDW,and P-LCR is of high value in the assessment of prognosis in pa-tients with ACS.
acute coronary syndromeplatelet morphology parametersseverity of coronary lesionprognosis
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维普
