Relationships between serum ANXA2 and ADAMTS4 levels and character of carotid plaque in patients with transient ischemic attack
Objective To investigate the relationships between serum levels of membrane-bound protein A2(ANXA2),a disintegrin and metalloproteinase with thrombospondin motifs-4(ADAMTS4)and character of carotid plaque in patients with transient ischemic attack(TIA).Methods Totally 156 patients with TIA(observation group)were selected for carotid artery vascular ultrasound,and 78 healthy volunteers undergoing physical examination during the same period(control group)were selected.The peripheral venous blood was collected from all the study subjects,centrifuged and retained for serum,and serum ANXA2 and ADAMTS4 were detected by ELISA.Patients with TIA were admitted to the hospital and underwent carotid vascular ultrasound to assess carotid plaque formation and stability by two experienced imaging physicians.Risk factors for carotid plaque instability in TIA patients were analyzed using multifactorial Logistic regression model.The predictive value of serum ANXA2 and ADAMTS4 levels for carotid plaque instability in TIA patients was analyzed using the receiver operating characteristic(ROC)curve.Results The serum ANXA2 and ADAMTS4 levels of the observation group were higher than those of the control group(t=16.636,25.358,both P<0.05).Carotid artery vascular ultrasound examination revealed that there were 76 cases of carotid plaque instability and 80 cases of carotid plaque stability or no carotid plaque in TIA patients,and the incidence of carotid plaque instability was 48.72％(76/156).Univariate analysis revealed that carotid plaque instability in TIA patients was associated with age,smoking,alcohol consumption,comorbid hypertension,stroke risk,and serum ANXA2 and ADAMTS4 levels(all P<0.05);multi-factorial Logistic regression analysis showed that smoking,alcohol consumption,increased risk of stroke,and elevated serum ANXA2 and ADAMTS4 levels were the independent risk factors for carotid plaque instability(all P<0.05).ROC curve analysis showed that the AUC of serum ANXA2 and ADAMTS4 levels alone and in combination in predicting carotid plaque instability in TIA patients was 0.787,0.780,and 0.874,respectively,and the AUC of serum ANXA2 and ADAMTS4 levels in predicting carotid plaque instability in TIA patients was greater than that of either alone(Z=3.151,3.326,both P<0.05).Conclusion Serum ANXA2 and ADAMTS4 levels increased in patients with TIA,and the elevated levels of them are independent risk factors for carotid plaque instability;serum ANXA2 and ADAMTS4 levels have a certain predic-tive value for carotid plaque instability in patients with TIA,and the predictive value of them combined is higher.
transient ischemic attackannexin A2A disintegrin and metalloproteinase with thrombospondin motifs-4atherosclerotic plaquecharacter of plaque
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