Curative effect of acupuncture at Guanyuan acupoint and Sanyinjiao acupoint in the treatment of primary dysmenorrhea and its influence on brain function
Objective To explore the central analgesic mechanism of acupuncture at Guanyuan acupoint and Sanyin-jiao acupoint in treatment of primary dysmenorrhea(PDM).Methods Twenty patients in the PDM group and 27 healthy control group were included.The resting-state functional magnetic resonance imaging(rs-fMRI)scans were performed on the 1st to 3st days of menstruation respectively.In the PDM group,acupuncture at Guanyuan acupoint and Sanyinjiao acu-point was performed continuously one week before the next menstrual period until menstruation began.Visual analogue scale(VAS)for pain,Cox menstrual symptom scale(CMSS),self-rating Anxiety Scale(SAS),and self-rating Depression Scale(SDS)were used to evaluate clinical symptoms.SPM and DPARSFA software based on Matlab platform were used for data preprocessing,regional homogeneity(ReHo)statistical parameters and brain function images,and the difference in ReHo values before and after acupuncture treatment was compared.Results The VAS,CMSS,SAS,and SDS scores decreased after acupuncture in comparison with those before treatment in patients of the PDM group(all P<0.01).After acupuncture,the ReHo values of left temporal pole and superior temporal gyrus,left precentral gyrus and postcentral gyrus increased significantly in PDM patients,while ReHo values decreased significantly in left middle temporal gyrus,bilateral precuneate lobe and left peri-talar fissure cortex.Compared with the healthy control group,ReHo increased in right dorso-lateral superior frontal gyrus and right insular lobe after,left superior temporal gyrus and left precentral gyrus,while ReHo decreased in right thalamus,left middle temporal gyrus,bilateral anterior cingulate and lateral cingulate gyrus and medial superior frontal gyrus in PDM group.Conclusion Acupuncture at Guanyuan acupoint and Sanyinjiao acupoint in the treatment of PDM mainly locates in the pain and emotion conduction pathway and limbic system,and alleviates PDM pain by regulating the brain function of pain-related brain areas.
acupunctureprimary dysmenorrhearesting-state functional magnetic resonance imagingcerebral function imagingregional homogeneitypaindepressionanxiety
万方数据
维普
