Value of monocyte/HDL-C ratio in the differential diagnosis of benign and malignant thyroid nodules in reproductive-aged women
Objective To investigate the value of monocyte/high-density lipoprotein cholesterol(HDL-C)ratio(MHR)in the differential diagnosis of benign and malignant thyroid nodules in reproductive-aged women.Methods A total of 186 reproductive-aged women with single thyroid nodule were selected as the observation group,and were divided into the malignant subgroup(23 cases)and benign subgroup(163 cases)according to surgical and pathological results;in the same period,93 healthy subjects who came to the hospital for physical examination were used as the control group.The clinical data of the malignant subgroup and benign subgroup were collected and compared.The peripheral blood mononu-clear cell and HDL-C were detected to calculate the MHR in each group.Multivariate Logistic regression was used to ana-lyze the effect of MHR on the thyroid nodules in reproductive-aged women.Hosmer-Lemeshow goodness of fit test was used to determine the fit of the model.Receiver operating characteristic curve(ROC curve)was used to analyze the diagnostic efficacy of MHR in preoperative thyroid nodules in reproductive-aged women.Results The MHR of observation group was higher than that of control group,and the MHR of malignant subgroup was higher than that of benign subgroup(both P<0.05).The proportion of tea drinking,education level,sleep time,frequency of physical exercise,frequency of eating aquatic products/seafood and eggs in the malignant subgroup were lower than those in the benign subgroup,and the propor-tion of diabetes,uterine fibroids,life and work stress,anxiety and depression,anger frequency,and depression in the past 1 year were higher than those in the benign subgroup(all P<0.05).Multilevel Logistic regression analysis was con-ducted.The results showed that when MHR was not included in model 1,life and work pressure,anxiety and depression,and anger frequency were independent risk factors for malignant thyroid nodules in reproductive-aged women(all P<0.05).When MHR was included in model 2,life and work pressure,anger frequency,and MHR were independent risk factors for malignant thyroid nodules in reproductive-aged women(all P<0.05).Using the predicted probability of the Lo-gistic regression analysis as the independent test variable,when MHR was not included,the AUC value of logit(P1)for dif-ferential diagnosis of thyroid nodules in reproductive-aged women was 0.745;when MHR was included,the AUC value of logit(P2)for differential diagnosis of thyroid nodules in reproductive-aged women was 0.925,which was greater than that without MHR(P<0.01).Conclusion The MHR of malignant thyroid nodules increases in reproductive-aged women,MHR is an independent risk factor for malignant thyroid nodules in reproductive-aged women,and detection of MHR is helpful to distinguish benign and malignant thyroid nodules in reproductive-aged women.
万方数据
维普
