Predictive value of serum sFlt-1 and sEng levels in acute kidney injury of patients with preeclampsia
Objective To analyze the predictive value of serum levels of soluble FMS-like tyrosine kinase 1(sFlt-1)and soluble endothelial glycoprotein(sEng)in women with preeclampsia(PE)complicated with acute kidney injury(AKI).Methods Eighty-four pregnant women with PE were selected as the observation group,and divided into the non-AKI group of 51 cases and AKI group of 33 cases.Additionally,82 healthy pregnant women without pregnancy-induced hypertension were selected as the control group.The clinical data of the control group,the non-AKI group,and the AKI group were collected and observed.Serum sFlt-1 and sEng levels were detected by ELISA in the control group,non-AKI group,and AKI group.The relationships between serum sFlt-1 and sEng expression levels and clinical data in the AKI group was compared.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum sFlt-1,sEng and their combination in predicting AKI in patients with PE.Results There were significant differences in renal function,urine routine,blood lipid and blood pressure among the control group,non-AKI group and AKI group(all P<0.05).The serum levels of sFlt-1 and sEng in the non-AKI group were lower than those in the AKI group,but were higher than those in the control group,with statistically significant differences(all P<0.05).Using the median relative expres-sion levels of serum sFlt-1 and sEng as the boundary value,the individuals with high levels of sFlt-1 and sEng had higher serum creatinine,urea nitrogen,24-hour proteinuria,systolic blood pressure,and diastolic blood pressure,and had lower glomerular filtration rate and 24-hour urine volume,in comparison with those with low levels,with statistically significant differences(all P<0.05).The area under the curve(AUC)of sFlt-1,sEng and their combination in diagnosing PE with AKI was 0.746,0.793,and 0.854,respectively.The sensitivities of sFlt-1,sEng,and their combination were 75.80%,78.80%,and 87.90%,respectively.Compared with the single detection of sFlt-1 or sEng,the combined detection of the two had higher predictive value(both P<0.05).Conclusion The combined detection of serum sFlt-1 and sEng has a high predictive effect on PE complicated with AKI.
万方数据
维普
