Value of placental microvascular index and serum TIMP-2 level in predicting fetal growth restriction in preeclampsia pregnant women
Objective To investigate the predictive value of placental microvascular index combined with serum ma-trix metalloproteinase inhibitor 2(TIMP-2)levels in fetal growth restriction(FGR)in pregnant women with preeclampsia(PE).Methods A total of 139 PE pregnant women(observation group),including 41 with FGR,98 without FGR,and meanwhile,50 normal pregnant women(control group)were selected.On the day after admission in the observation group and on the day of physical examination in the control group,the placental microvascular examination was performed by three-dimensional ultrasonic diagnostic instrument,and the placental microvascular index,including vascularization index(VI),blood flow index(FI)and vascularization-flow index(VFI),was recorded.Fasting peripheral venous blood was col-lected,serum was retained by centrifugation,and serum TIMP-2 was detected by double antibody enzyme-linked immuno-sorbent assay.The risk factors of FGR in PE pregnant women were analyzed,and the predictive value of placental micro-vascular index and serum TIMP-2 level for FGR in PE pregnant women was analyzed by receiver operating characteristic(ROC)curve.Results The placental microvascular indexes VI,FI and VFI levels in the observation group were lower than those in the control group,and the serum TIMP-2 level was higher than that in the control group(all P<0.05).Uni-variate analysis showed that the placental microvascular indexes VI,FI and VFI of the PE pregnant women with FGR were lower than those in PE pregnant women without FGR,while the serum TIMP-2 level was higher(all P<0.05).Multivari-ate Logistic regression analysis showed that the decreased placental microvascular indexes VI,FI and VFI and the in-creased serum TIMP-2 were independent risk factors for FGR in PE pregnant women(all P<0.05).ROC curve analysis showed that the area under the curve(AUC)of placental microvascular indexes VI,FI,VFI and serum TIMP-2 in predict-ing the occurrence of FGR in PE pregnant women was 0.792,0.797,0.821 and 0.696,respectively,and the AUC of the four combined in predicting the occurrence of FGR in PE pregnant women was 0.949.The AUC of the combination of pla-cental microvascular indexes VI,FI,VFI and serum TIMP-2 in predicting FGR in PE pregnant women was higher than that of the four alone(all P<0.05).Conclusions The decreased placental microvascular indexes VI,FI and VFI and the increased serum TIMP-2 level are independent risk factors for FGR in PE pregnant women.The placental microvascu-lar indexes VI,FI,VFI and serum TIMP-2 have certain predictive value for the occurrence of FGR in PE pregnant wom-en,and the predictive value of the four combined is higher.
preeclampsiafetal growth restrictionplacental microvascular indexmatrix metalloproteinase inhibi-tor 2predictive value
万方数据
维普
