Relationships between serum Leptin and Apelin levels and visual disability after vitrectomy in patients with proliferative diabetic retinopathy
Objective To investigate the relationships of serum Leptin and Apelin levels with visual disability after vitrectomy(PPV)in patients with proliferative diabetic retinopathy(PDR).Methods Totally 198 patients(198 eyes)with PDR treated with PPV were selected and followed up for 1 year after PPV,and the patients were divided into the visu-al disability group of 48 cases and the sighted group of 150 cases according to the occurrence of visual disability.Clinical data of the two groups were collected;3 mL of fasting elbow vein blood was collected from PDR patients before PPV treat-ment,and serum Leptin and Apelin were detected by enzyme-linked immunosorbent assay;the effects of serum Leptin and Apelin levels on visual disability after PPV in PDR patients were analyzed by multifactorial Logistic regression.The predic-tive value of serum Leptin and Apelin levels on visual disability after PPV in PDR patients was analyzed by the receiver op-erating characteristic(ROC)curve.Results Compared with the sighted group,the visual disability group was older and had higher degree of PDR,proportion of preoperative iris neovascularization,glycated hemoglobin levels and serum Leptin and Apelin levels(all P<0.05).The results of multifactorial Logistic regression analysis showed that severe PDR,preop-erative iris neovascularization,elevated Leptin,and elevated Apelin were independent risk factors for visual disability af-ter PPV in patients with PDR(all P<0.05).The ROC curve showed that the area under the curve of serum Leptin and Apelin combined in predicting visual disability after PPV in PDR patients was 0.921,which was greater than that of either alone(both P<0.05).Conclusion Elevated serum Leptin and Apelin levels are risk factors for post-PPV visual disabili-ty in patients with PDR,and the combination of the two has a high predictive value for post-PPV visual disability in pa-tients with PDR.
万方数据
维普
