Relationship between viral infection and acute kidney injury in patients with severe pneumonia based on propensity score matching
Objective To analyze the relationship between viral infection and acute kidney injury(AKI)in severe pneumonia patients using propensity score matching(PSM),in order to provide clinical treatment guidance.Methods A total of 169 patients with severe pneumonia,including 77 virus-infected patients and 92 non-virus-infected patients,were selected by a 1:1 propensity score matching method,and were divided into the virus-infected group of 60 cases and non-vi-rus-infected group of 60 cases.The basic data of patients in the two groups were collected,including age,sex,tempera-ture,length of stay,complications,white blood cell count at admission,lymphocyte(Lym)count,hemoglobin(Hb),C-reactive protein(CRP),calcitonin(PCT),prothrombin time(PT),activated partial thromboplastin time(APTT),D-dimer,sodium,potassium,albumin,PH during hospitalization,PaCO2,PaO2,lactic acid,eGFR,baseline Scr,whether ACEI was used,whether ARB was used,whether diuretics were used,whether hypoglycemic agents were used,and whether glucocorticoids were used.Prognostic data,including AKI,in-hospital death,use of mechanical ventilation(MV)and continuous renal replacement therapy(CRRT),were collected in both groups.Results No significant differ-ences were found in the age,gender,body temperature,or other basic data between these two groups(all P>0.05).The incidence of AKI,in-hospital mortality and MV use rate in the virus infection group were higher than those in the non-virus infection group(all P<0.05).The results of conditional Logistics regression analysis showed that viral infection was an in-dependent risk factor for AKI in patients with severe pneumonia(OR=2.982,95%CI:1.068-8.329,P=0.037).Conclu-sion After the confounding factors were excluded by PSM,viral infection was an independent risk factor for AKI in pa-tients with severe pneumonia.
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