Changes in levels of serum S100 calcium binding protein and osteopontin in children with mycoplasma pneumoniae pneumonia at admission and their predictive efficacy for prognosis
Objective To observe the levels of serum S100 calcium binding protein A8/A9(S100A8/A9)and os-teopontin(OPN)in children with mycoplasma pneumoniae pneumonia(MPP)at admission,and to analyze their prognos-tic predictive efficacy.Methods A total of 211 children with MPP[MPP group,including 138 cases of severe mycoplas-ma pneumoniae pneumonia(SMPP)and 73 cases of general mycoplasma pneumoniae pneumonia(GMPP)]and 110 healthy children(control group)were enrolled.Enzyme-linked immunosorbent assay was used to detect serum S100A8/A9 and OPN in the two groups at admission.MPP children(211 cases)were divided into the poor prognosis group(62 cas-es)and good prognosis group(149 cases)according to the prognosis at 28 days after admission.Univariate and multivari-ate Logistic regression analyses were used to analyze the influencing factors and risk factors of poor prognosis at 28 days af-ter admission in children with MPP,and receiver operating characteristic(ROC)curve was drawn to evaluate the efficacy of serum S100 A8/A9 and OPN levels in predicting poor prognosis in children with MPP.Results The levels of serum S100A8/A9 and OPN in the MPP group were higher than those in the control group at admission(both P<0.05).The lev-els of serum S100A8/A9 and OPN in SMPP patients were higher than those in GMPP patients(both P<0.05).The inde-pendent risk factors of poor prognosis in children with MPP were S100A8/A9,OPN,procalcitonin and SMPP,prolonged hospitalization time(all P<0.05).When the cut-off value of serum S100A8/A9 was 1.01 ng/mL,the AUC in predicting the poor prognosis of children with MPP was 0.789(95%CI:0.728-0.842),the sensitivity was 100.00%,and the specificity was 48.32%;when the cut-off value of serum OPN was 24.13 ng/mL,the AUC in predicting poor prognosis in children with MPP was 0.781(95%CI:0.719-0.835),the sensitivity was 82.26%,and the specificity was 60.40%;the AUC of serum S100A8/A9 combined with OPN in predicting the poor prognosis of children with MPP was 0.867(95%CI:0.814-0.910),the sensitivity was 88.82%,and the specificity was 76.81%.Conclusion The lev-els of serum S100A8/A9 and OPN in children with MPP at admission were higher than those in healthy children,the lev-els of S100A8/A9 and OPN in children with SMPP were higher than those in children with GMPP,the two indexes were related to the severity of the disease and poor prognosis,they were independent risk factors for poor prognosis of children with MPP at 28 days after admission,and the combined detection was more helpful to evaluate the poor prognosis than sin-gle detection.
S100 calcium binding protein A8/A9osteopontinmycoplasma pneumoniae pneumoniamycoplas-ma pneumoniae pneumonia in childrenthe severity of the diseaseprognosis of patients
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