Synthesis of HIV Non-nucleotide Reverse Transcriptase Inhibitors
Acquired immunodeficiency syndrome,as a silent and deadly killer,is one of the most serious infectious diseases in the world today.Reverse transcriptase is an important protein required for the proliferation of HIV virus,and currently non nucleotide reverse transcriptase inhibitors are widely used due to their high specificity.This article will focus on the chemical synthesis of three classic HIV non nucleotide reverse transcriptase inhibitors,Rilpivirine,Etavirine,and Doravirine.Starting from the initial low yield and time-consuming synthesis,the goal of synthesis optimization is achieved through microwave radiation,orthogonal experiments,and organic metal catalytic reactions.The process of optimization is not limited to improving the reaction route,but also to small-scale optimization of reaction parameters based on the reaction route.
organic synthesisoptimization of organic synthesisacquired immunodeficiency syndromenon nucleotide reverse transcriptase
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维普
