Study of Bisphosphonates and Their Application in OVCFs
The biological effects of bisphosphonates(BP)as inhibitors of calcification and bone resorption were first described in the late 1960s.In the 50 years since then,BP has become the main drug for the treatment of bone diseases characterized by increased bone resorption,these include Paget's bone disease,bone metastases,multiple myeloma,osteoporosis,and several childhood genetic disorder.The discovery and development of BP as a major class of drugs for bone disease is an example of a successful journey from the laboratory to the bedside and back again.The structure,pharmacology and application of bisphosphonates are introduced in this paper,which can be used as a reference for domestic researchers in this field.
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