药物双磷酸盐的研究及其在OVCFs中的应用
Study of Bisphosphonates and Their Application in OVCFs
于伏龙 1李荣锐 2王硕 1王钞 1张深越1
作者信息
- 1. 佳木斯大学,黑龙江 佳木斯 154000
- 2. 佳木斯大学附属第一医院,黑龙江 佳木斯 154000
- 折叠
摘要
双膦酸盐(BP)作为钙化和骨吸收抑制剂的生物学效应在20 世纪 60年代后期首次被描述.之后的 50年里,BP已成为治疗以骨吸收增加为特征的骨骼疾病的主要药物,包括佩吉特骨病、骨转移、多发性骨髓瘤、骨质疏松症和几种儿童遗传性疾病.本文简要介绍了双磷酸盐的结构,对其药理学及应用进行了相关阐述,为国内此领域的药物应用人员提供了参考.
Abstract
The biological effects of bisphosphonates(BP)as inhibitors of calcification and bone resorption were first described in the late 1960s.In the 50 years since then,BP has become the main drug for the treatment of bone diseases characterized by increased bone resorption,these include Paget's bone disease,bone metastases,multiple myeloma,osteoporosis,and several childhood genetic disorder.The discovery and development of BP as a major class of drugs for bone disease is an example of a successful journey from the laboratory to the bedside and back again.The structure,pharmacology and application of bisphosphonates are introduced in this paper,which can be used as a reference for domestic researchers in this field.
关键词
双磷酸盐/药物/骨质疏松性椎体压缩性骨折(OVCFs)Key words
bisphosphonate/drug/osteoporotic vertebral compression fracture引用本文复制引用
出版年
2024
NETL
NSTL
万方数据