Study on the Synthesis Process of Dabigatran Ester,a Drug for Thromboembolic Diseases
Study the synthesis process of the drug dabigatran ester for thromboembolic diseases,and improve the reaction yield and extraction purity of dabigatran ester.Based on the overview and basic synthesis methods of dabigatran ester,improve the synthesis process of dabigatran ester.Determine the optimal reaction conditions through repeated experiments.Experiments have shown that compound 2 can be obtained by alcoholysis at 1.5 eq acetyl chloride,ammonolysis at 20℃,and salt formation of p-toluenesulfonic acid at 3.0 eq.Compound 3 can be obtained by using dichloromethane as the reaction solvent,which can save investment costs,improve reaction yield and extraction purity.
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