This paper aimed to study the energy saving and consumption reduction of a 150,000 t/a MTBE unit in an oil refinery,in order to propose a variety of innovative schemes to improve the energy consumption and economic benefits of the unit.Firstly,it studied various sources of energy consumption during MTBE production,including pre-treatment,reaction and separation.Then,it proposed a series of innovative energy-saving measures and carried out experimental verification.In the early stage of the process,the product purification washing operation was adjusted to reduce the impurity content in carbon 4,and effectively reduced the energy consumption in the production process of MTBE.At the same time,it had innovatively optimized the alcohol-ene ratio to maximize the reaction between isobutylene and methanol,thereby reducing energy consumption.In addition,by reducing the steam consumption of the catalytic distillation tower and the methanol recovery tower,and recovering the waste heat,the expected goal was successfully achieved.Compared to conventional MTBE units,the solution significantly reduces energy consumption and improves economic efficiency.In summary,comprehensive experiments and simulation studies were carried out for different operating conditions to evaluate the influence of each process parameter on energy consumption.These innovative measures can not only reduce energy consumption and improve economic efficiency,but also provide valuable innovation reference for similar units in other refineries.