Synthesis of Impurities Related to Luteinib Phosphate
Based on the synthesis method of the raw material of rutinib phosphate,potential process impurities that may occur during the synthesis process were analyzed and synthesized.Three potential impurities were synthesized using 6-chloro-7-azepurine as the starting material through substitution reaction,coupling reaction,and hydrolysis reaction.The purity was detected by high performance liquid chromatography to be greater than 97.0%.The synthesis method has the characteristics of simple preparation process and high impurity purity.The chemical structure of the compound was confirmed by nuclear magnetic resonance hydrogen spectrum and carbon spectrum,as well as liquid chromatography-mass spectrometry.The structural confirmation data is consistent with the target compound,and it can be used as a reference substance for the analysis and identification of unknown impurities in phosphorutinib.
bone marrow fibersluteinib phosphateimpurity synthesis
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