Biomimetic MOF Drug Delivery System Based on ROS Storm Strategy for Efficient Iron Death Treatment of Breast Cancer
OBJECTIVE:A metal-organic framework(MOF)carrier material was chemically synthesised and explored for efficient ferroptosis therapy in breast cancer.METHODS:A porous iron-based metal-organic framework(Fe-MOF)carrier was synthesised by solvothermal synthesis,and a biomimetic MOF delivery system(R@Fe-DA MOFs)was constructed by non-solvent loading of dihydroartemisinin(DA)and surface modification of cancer cell membranes,and systematic evaluations of morphology,drug loading,anticancer activity,and anticancer mechanism were performed.RESULTS:The R@Fe-DA MOFs were homogeneous in particle size and had high drug loading capacity.The in vitro tumour suppressive effect was good.The cellular ROS content was high.The cellular uptake was ideal,and the longer the time,the more adequate the uptake.R@Fe-DA MOFs had the strongest in vivo effect and good biosafety.CONCLUSION:R@Fe-DA MOFs are a potentially superior delivery system and valuable for the clinical development of dihydroartemisinin.
ROSdihydroartemisininFe-based organic frameworkbreast cancer
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